# paired box 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120414](https://www.wikidata.org/wiki/Q21120414)  
**Source**: https://4ort.xyz/entity/paired-box-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q02962)
3. Q20641742
4. [Further delineation of renal-coloboma syndrome in patients with extreme variability of phenotype and identical PAX2 mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
6. [Mutations in PAX2 associate with adult-onset FSGS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02962&geneProductId=UniProtKB:Q02962)
8. [PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
9. [Prolyl hydroxylase domain protein 3 targets Pax2 for destruction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
10. [Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
11. [Interaction of the LMX1B and PAX2 gene products suggests possible molecular basis of differential phenotypes in Nail-Patella syndrome.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
12. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
13. [The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
14. [Novel interaction partners of Bardet-Biedl syndrome proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
15. [WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
16. [Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
17. [PAX2 suppresses apoptosis in renal collecting duct cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
18. [A common variant of the PAX2 gene is associated with reduced newborn kidney size](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
19. [Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
20. [The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
21. [WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02962&geneProductId=UniProtKB:Q02962)
22. [Mutations in PAX2 associate with adult-onset FSGS](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02962&geneProductId=UniProtKB:Q02962)
23. [PAX2 activates WNT4 expression during mammalian kidney development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02962&geneProductId=UniProtKB:Q02962)
24. [Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02962&geneProductId=UniProtKB:Q02962)
25. [PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
26. [Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
27. [PAX2 activates WNT4 expression during mammalian kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02962)
28. Ensembl Release 99
29. UMLS 2023