# Paired box 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988398](https://www.wikidata.org/wiki/Q21988398)  
**Source**: https://4ort.xyz/entity/paired-box-2-q21988398


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P32114)
3. Q20641742
4. [Pax genes and their role in organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
5. [Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
7. [Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
8. [Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
9. [Repression of Pax-2 by WT1 during normal kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
10. [A Hox-Eya-Pax complex regulates early kidney developmental gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
11. [Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
12. [PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
13. [Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
14. [Pax genes and their role in organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
15. [Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
16. [Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
17. [Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
18. [Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
19. [Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
20. [Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
21. [Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
22. [Pax2 contributes to inner ear patterning and optic nerve trajectory](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
23. [Nephric lineage specification by Pax2 and Pax8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
24. [Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
25. [Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
26. [Pax-2 controls multiple steps of urogenital development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
27. [PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells from programmed cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
28. [PAX2 suppresses apoptosis in renal collecting duct cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
29. [Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
30. [Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
31. [The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
32. [Vesicoureteral Reflux and Other Urinary Tract Malformations in Mice Compound Heterozygous for Pax2 and Emx2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
33. [Requirement of Lim1 for female reproductive tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
34. [Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
35. [Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
36. [Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
38. [Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32114&geneProductId=UniProtKB:P32114)
39. [Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
40. [Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
41. [PAX2 activates WNT4 expression during mammalian kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
42. [Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
43. [Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
44. [Pax2 overexpression in embryoid bodies induces upregulation of integrin alpha8 and aquaporin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
45. [Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
46. [Vax genes ventralize the embryonic eye](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
47. [Optic nerve axon number in mouse is regulated by PAX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
48. [The role of Pax2 in mouse inner ear development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
49. [Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)
50. [Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32114)