# P21 (RAC1) activated kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130016](https://www.wikidata.org/wiki/Q21130016)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PAK2)  
**Source**: https://4ort.xyz/entity/p21-rac1-activated-kinase-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13177)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
6. [Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
7. [Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
9. [Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
10. [Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
11. [Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
12. [VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
13. [The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
14. [Identification of the Nef-associated kinase as p21-activated kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
15. [Scrib regulates PAK activity during the cell migration process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
16. [betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
17. [Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
18. [A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
19. [Huntingtin promotes cell survival by preventing Pak2 cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
20. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
22. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
23. [Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
24. [WNT-3a modulates platelet function by regulating small GTPase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
25. [Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
26. [PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
27. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
28. [POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
29. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
30. [Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
31. [Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
33. [The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
34. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
35. [A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177)
36. [Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177)
37. Ensembl Release 99