# P21 (RAC1) activated kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7118116](https://www.wikidata.org/wiki/Q7118116)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PAK1)  
**Source**: https://4ort.xyz/entity/p21-rac1-activated-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13153)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
5. [A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
6. [The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
7. [PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
8. [Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
9. [Scrib regulates PAK activity during the cell migration process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
10. [Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
11. [srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
12. [EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
13. [Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
14. [The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
15. [A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
16. [Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
17. [DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
18. [Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
19. [ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
20. [IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
21. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
22. [Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
23. [Nox1 activation by βPix and the role of Ser‐340 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
24. [Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
25. [Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
26. [The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
27. [A genetically encoded photoactivatable Rac controls the motility of living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
28. [Caveolin-1 Mediates Salmonella Invasion via the Regulation of SopE-dependent Rac1 Activation and Actin Reorganization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
29. [An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
30. [Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
31. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
32. [Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
33. [14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
34. [Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
35. [Localized Rac activation dynamics visualized in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
36. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
37. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
38. [CRIPak, a novel endogenous Pak1 inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
39. [GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
40. [Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
41. [Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
42. [Affixin activates Rac1 via betaPIX in C2C12 myoblast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
43. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
44. [ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
45. [RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
46. [DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
47. [Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
48. [Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
49. [Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153)
50. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153)