# cyclin dependent kinase inhibitor 2A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q416259](https://www.wikidata.org/wiki/Q416259)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/P16)  
**Source**: https://4ort.xyz/entity/p16


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42771)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
6. [The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
7. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
8. [A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
9. [Functional characterization of human PFTK1 as a cyclin-dependent kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
10. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
11. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
12. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
13. [Proteomic analysis of p16ink4a-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
14. [A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
15. [Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
16. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
17. [Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
18. [The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
19. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
20. [A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
21. [A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
22. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
23. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
24. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
27. [Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
28. [A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
30. [Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
31. [p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
32. [Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
33. [Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42771&geneProductId=UniProtKB:P42771)
34. [The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
35. [Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
36. [Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
37. [Growth suppression by p16ink4 requires functional retinoblastoma protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
38. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42771)
39. Ensembl Release 99
40. Identifiers.org
41. UMLS 2023