# Overcoming the preferred-orientation problem in cryo-EM with self-supervised deep learning

> Research article (Nature Methods, 2024) · cited 43× · AI/ML

**Wikidata**: [openalex:W4404460735](https://www.wikidata.org/wiki/openalex:W4404460735)  
**Source**: https://4ort.xyz/entity/overcoming-the-preferred-orientation-problem-in-cryo-em-with-self-supervised-deep-learning