# OTU deubiquitinase with linear linkage specificity

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112127](https://www.wikidata.org/wiki/Q21112127)  
**Source**: https://4ort.xyz/entity/otu-deubiquitinase-with-linear-linkage-specificity


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96BN8)
3. Q20641742
4. [OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
6. [The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
7. [Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
8. [The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
9. [Molecular Basis and Regulation of OTULIN-LUBAC Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
10. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
12. [CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
13. [OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
14. [OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
15. [Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
16. [Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
17. [The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
18. [Molecular Basis and Regulation of OTULIN-LUBAC Interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
19. [OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8)
20. [OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
21. [OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
22. [Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
23. [CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8)
25. Ensembl Release 99