# Optineurin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7098997](https://www.wikidata.org/wiki/Q7098997)  
**Source**: https://4ort.xyz/entity/optineurin-q7098997


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96CV9)
3. Q20641742
4. [Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
5. [Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
6. [Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
7. [Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
8. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
9. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
10. [Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
11. [Interaction between optineurin and the bZIP transcription factor NRL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
12. [Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
13. [The TBK1-binding domain of optineurin promotes type I interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
14. [Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
15. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
16. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
17. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
18. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
19. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
20. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
21. [Huntingtin interacting proteins are genetic modifiers of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
22. [Development and application of a DNA microarray-based yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
23. [Cargo binding induces dimerization of myosin VI.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
24. [Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
25. [Identification and comparative analysis of hepatitis C virus-host cell protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
26. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
27. [Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96CV9&geneProductId=UniProtKB:Q96CV9)
31. [Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96CV9&geneProductId=UniProtKB:Q96CV9)
32. [A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96CV9&geneProductId=UniProtKB:Q96CV9)
33. [Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96CV9&geneProductId=UniProtKB:Q96CV9)
34. [Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
35. [A novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
36. [Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9)
37. Ensembl Release 99