# Optimization of Protein–Ligand Electrostatic Interactions Using an Alchemical Free-Energy Method

> Research article (Journal of Chemical Theory and Computation, 2019) · cited 14× · AI/ML

**Wikidata**: [openalex:W2979016730](https://www.wikidata.org/wiki/openalex:W2979016730)  
**Source**: https://4ort.xyz/entity/optimization-of-proteinligand-electrostatic-interactions-using-an-alchemical-free-energy-method