# Opioid receptor, mu 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561662](https://www.wikidata.org/wiki/Q28561662)  
**Source**: https://4ort.xyz/entity/opioid-receptor-mu-1-q28561662


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P33535)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
6. [The μ-Opioid Receptor Down-Regulates Differently from the δ-Opioid Receptor: Requirement of a High Affinity Receptor/G Protein Complex Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
7. [Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
8. [Activation of μ opioid receptors inhibits transient high- and low-threshold Ca 2+ currents, but spares a sustained current](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
9. [Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
10. [Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
11. [Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
12. [ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
13. [Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
14. [Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
15. [Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
16. [Retracted: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling and CREB Activation of Acute Morphine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
17. [Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
18. [Side Chain Modifications Change the Binding and Agonist Properties of Endomorphin 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
19. [G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
20. [Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
21. [Integrins regulate opioid receptor signaling in trigeminal ganglion neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
22. [Ultrastructural evidence for co-localization of corticotropin-releasing factor receptor and mu-opioid receptor in the rat nucleus locus coeruleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
23. [Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
24. [Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
25. [Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
26. [-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33535&geneProductId=UniProtKB:P33535)
27. [Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
28. [Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
29. [Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
30. [A naloxonazine sensitive (mu1 receptor) mechanism in the parabrachial nucleus modulates eating](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
31. [Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
32. [Expression of beta-endorphin and micro-opioid receptor during wound healing process in rat with deep partial-thickness scald](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
33. [Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
34. [NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
35. [Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
36. [Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
37. [Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
38. [Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
39. [kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
40. [Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
41. [Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
42. [Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
43. [Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
44. [-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33535)
45. ensembl Release 104