# OPA1, mitochondrial dynamin like GTPase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560345](https://www.wikidata.org/wiki/Q28560345)  
**Source**: https://4ort.xyz/entity/opa1-mitochondrial-dynamin-like-gtpase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q2TA68)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
6. [Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
7. [Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
8. [Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
9. [Regulation of mitochondrial morphology through proteolytic cleavage of OPA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
10. [Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
11. [Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
12. [OPA1 loss of function affects in vitro neuronal maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
13. [Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
14. [In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
15. [Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
16. [Impaired balance of mitochondrial fission and fusion in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
17. [Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
18. [Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
19. [OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
20. [High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
21. [Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
22. [OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
23. [Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
24. [Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2TA68)
25. ensembl Release 104