# OPA1 mitochondrial dynamin like GTPase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21106682](https://www.wikidata.org/wiki/Q21106682)  
**Source**: https://4ort.xyz/entity/opa1-mitochondrial-dynamin-like-gtpase-q21106682


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60313)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
5. [WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
6. [ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
7. [Vital function of PRELI and essential requirement of its LEA motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
8. [Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
9. [The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
10. [SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
11. [OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
13. [OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
15. [OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
16. [OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
17. [A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
18. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
19. [Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
20. [Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
21. [Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
22. [Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
23. [Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
24. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
25. [Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
26. [The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
27. [OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
28. [Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313)
29. [Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313)
30. Ensembl Release 99
31. Transporter Classification database