# Nucleotide binding oligomerization domain containing 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q416481](https://www.wikidata.org/wiki/Q416481)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/NOD2)  
**Source**: https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9HC29)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
7. [CLAN, a novel human CED-4-like gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
8. [The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
9. [The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
10. [A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
11. [Role for erbin in bacterial activation of Nod2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
12. [Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
13. [TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
14. [An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
15. [A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
16. [Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
17. [TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
18. [TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
19. [GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
20. [Endosomes are specialized platforms for bacterial sensing and NOD2 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
21. [The intermediate filament protein, vimentin, is a regulator of NOD2 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
22. [A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
23. [Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
24. [Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
25. [Evaluation of Nod-like receptor (NLR) effector domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
26. [Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
27. [Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
28. [Reciprocal cross-talk between Nod2 and TAK1 signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
29. [IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
30. [NLRs join TLRs as innate sensors of pathogens](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
32. [Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
33. [The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
34. [Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
35. [Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
36. [Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
37. [Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
38. [The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
39. [NLRs join TLRs as innate sensors of pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
41. [IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
42. [Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
43. [Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
44. [Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
45. [Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29)
46. [The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
47. [OTULIN restricts Met1-linked ubiquitination to control innate immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
48. [Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
49. [A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)
50. [Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29)