# Nucleotide-binding oligomerization domain containing 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21990361](https://www.wikidata.org/wiki/Q21990361)  
**Source**: https://4ort.xyz/entity/nucleotide-binding-oligomerization-domain-containing-2-q21990361


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8K3Z0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
5. [Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
6. [NLRs join TLRs as innate sensors of pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
7. [Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
8. [The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
9. [NLRs join TLRs as innate sensors of pathogens](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
12. [Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
13. [TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
14. [Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
15. [Intracellular Pathogen Sensor NOD2 Programs Macrophages to Trigger Notch1 Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
16. [Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
17. [Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
18. [NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
19. [PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
20. [The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
21. [Critical role of NOD2 in regulating the immune response to Staphylococcus aureus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
22. [Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
23. [The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
24. [Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
25. [The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
26. [A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K3Z0)
27. [Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
28. [Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
29. [NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K3Z0&geneProductId=UniProtKB:Q8K3Z0)
31. ensembl Release 106