# Nucleophosmin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21117747](https://www.wikidata.org/wiki/Q21117747)  
**Source**: https://4ort.xyz/entity/nucleophosmin-1-q21117747


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2403108)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06748)
4. Q20641742
5. [Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
6. [Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748)
8. [Nucleolar protein B23 has molecular chaperone activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748)
9. [Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
10. [A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
11. [A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748)
12. [Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
13. [Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748)
14. [Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
15. [Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748)
16. [Detection and identification of transcription factors as interaction partners of alien in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
17. [Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
18. [DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
19. [The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
20. [Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
21. [Nucleophosmin is essential for ribosomal protein L5 nuclear export](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
22. [APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
23. [Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
24. [Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
25. [Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
26. [PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
27. [Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
28. [Nucleophosmin regulates the stability and transcriptional activity of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
29. [Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
30. [The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
31. [HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
32. [Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
33. [AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
34. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
35. [Erythroid differentiation‐associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
36. [Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
37. [Nucleophosmin deposition during mRNA 3′ end processing influences poly(A) tail length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
38. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
39. [ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
40. [Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
41. [Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
42. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
43. [The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
44. [Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
45. [Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
46. [The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
47. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
48. [Antiviral action of the tumor suppressor ARF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
49. [Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)
50. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748)