# Nuclear receptor subfamily 1 group H member 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112289](https://www.wikidata.org/wiki/Q21112289)  
**Source**: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-3-q21112289


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13133)
4. Q20641742
5. [Role of LXRs in control of lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
6. [GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
7. [CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
8. [Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
9. [Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
10. [Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
11. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
12. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
13. [Molecular determinants of the interactions between SRC‐1 and LXR/RXR heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
14. [Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
15. [A Y2H-seq approach defines the human protein methyltransferase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
17. [LXR, a nuclear receptor that defines a distinct retinoid response pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
18. [Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
19. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
23. [The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
24. [The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
25. [LXR, a nuclear receptor that defines a distinct retinoid response pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
26. [CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
27. [Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
28. [Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
29. [Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
30. [Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
31. [Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
32. [FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
33. [GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
34. [Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
35. [Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
36. [Regulation of LPCAT3 by LXR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133)
37. [FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
38. [Regulation of LPCAT3 by LXR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
39. [Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133)
40. Ensembl Release 99