Nuclear receptor subfamily 1, group H, member 2
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: Friedrich Rückert
additional property: PropertyValue
  property ID: P361
  value: Nuclear hormone receptor-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, NHR/GATA-type
additional property: PropertyValue
  property ID: P361
  value: liver X receptor
additional property: PropertyValue
  property ID: P527
  value: Nuclear hormone receptor, ligand-binding domain
additional property: PropertyValue
  property ID: P527
  value: nuclear hormone receptor-type zinc finger
additional property: PropertyValue
  property ID: P637
  value: NP_001272446
additional property: PropertyValue
  property ID: P637
  value: NP_001272447
additional property: PropertyValue
  property ID: P637
  value: NP_001272448
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription factor activity
additional property: PropertyValue
  property ID: P680
  value: ATPase binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: positive regulation of high-density lipoprotein particle assembly
additional property: PropertyValue
  property ID: P682
  value: negative regulation of proteolysis
additional property: PropertyValue
  property ID: P682
  value: positive regulation of triglyceride biosynthetic process
additional property: PropertyValue
  property ID: P702
  value: Nr1h2
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000073188
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000103545
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000126788
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 24
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 24
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q60644
    source count: 1
    confidence: 0.2
    value label: Friedrich Rückert
  P361:
    value: Q41796865
    source count: 1
    confidence: 0.2
    value label: Nuclear hormone receptor-like domain superfamily
  P361:
    value: Q24768526
    source count: 1
    confidence: 0.2
    value label: Zinc finger, NHR/GATA-type
  P361:
    value: Q3454539
    source count: 1
    confidence: 0.2
    value label: liver X receptor
  P361:
    value: Q83140722
    source count: 1
    confidence: 0.2
    value label: Nuclear hormone receptor, ligand-binding domain, protein family
  P361:
    value: Q83135095
    source count: 1
    confidence: 0.2
    value label: Zinc finger, nuclear hormone receptor-type, protein family
  P527:
    value: Q24772746
    source count: 1
    confidence: 0.2
    value label: Nuclear hormone receptor, ligand-binding domain
  P527:
    value: Q24725588
    source count: 1
    confidence: 0.2
    value label: nuclear hormone receptor-type zinc finger
  P637:
    value: NP_001272446
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001272447
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001272448
    source count: 1
    confidence: 0.2
  P637:
    value: NP_033499
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006540867
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 3
    confidence: 0.6
    value label: DNA binding
  P680:
    value: Q14817979
    source count: 3
    confidence: 0.6
    value label: DNA-binding transcription factor activity
  P680:
    value: Q14873897
    source count: 2
    confidence: 0.4
    value label: ATPase binding
  P680:
    value: Q14633865
    source count: 1
    confidence: 0.2
    value label: zinc ion binding
  P680:
    value: Q14817973
    source count: 4
    confidence: 0.8
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q40260
    source count: 5
    confidence: 1.0
    value label: nucleus
  P681:
    value: Q40260
    source count: 6
    confidence: 1.0
    value label: nucleus

value: Q21095257
source count: 1
confidence: 0.2
value label: RNA polymerase II transcription regulator complex

value: Q21115217
source count: 2
confidence: 0.4
value label: positive regulation of high-density lipoprotein particle assembly

value: Q14758948
source count: 1
confidence: 0.2
value label: negative regulation of proteolysis

value: Q14872716
source count: 2
confidence: 0.4
value label: positive regulation of triglyceride biosynthetic process

value: Q14758925
source count: 2
confidence: 0.4
value label: positive regulation of protein metabolic process

value: Q21108027
source count: 2
confidence: 0.4
value label: positive regulation of cholesterol transport

value: Q18255253
source count: 1
confidence: 0.2
value label: Nr1h2

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000073188
source count: 1
confidence: 0.2

value: ENSMUSP00000103545
source count: 1
confidence: 0.2

value: ENSMUSP00000126788
source count: 1
confidence: 0.2

value: ENSMUSP00000103543
source count: 1
confidence: 0.2

value: ENSMUSP00000103544
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes
stated in qid: Q28591219
retrieved: 2019-02-14

source: Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors
stated in qid: Q28302085
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis
stated in qid: Q24316186
retrieved: 2019-02-14

source: SIRT1 deacetylates and positively regulates the nuclear receptor LXR
stated in qid: Q24297669
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression
stated in qid: Q28587690
retrieved: 2018-04-24

source: Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression
stated in qid: Q28587690
retrieved: 2019-02-14

source: Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
stated in qid: Q28513193
retrieved: 2019-02-14

source: Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting
stated in qid: Q28584943
retrieved: 2019-02-14

source: Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
stated in qid: Q28589168
retrieved: 2018-04-24

source: Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting
stated in qid: Q28584943
retrieved: 2018-04-24

source: Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
stated in qid: Q24320180
retrieved: 2018-04-24

source: Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
stated in qid: Q28592354
retrieved: 2018-04-24

source: Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
stated in qid: Q28513193
retrieved: 2018-04-24

source: Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
stated in qid: Q28589168
retrieved: 2019-02-14

source: Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
stated in qid: Q28592354
retrieved: 2019-02-14

source: Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
stated in qid: Q24320180
retrieved: 2019-02-14

source: Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity
stated in qid: Q34471849
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21989816
domain: protein
level: standard
html url: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2-q21989816
markdown url: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2-q21989816.md
facts url summary: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2-q21989816/facts.json
facts url standard: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2-q21989816/facts.json
facts url full: https://4ort.xyz/entity/nuclear-receptor-subfamily-1-group-h-member-2-q21989816/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T13:38:25.133586Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:56.656023+00:00Z