# Nuclear receptor corepressor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7068191](https://www.wikidata.org/wiki/Q7068191)  
**Source**: https://4ort.xyz/entity/nuclear-receptor-corepressor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75376)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
5. [Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
6. [Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
7. [The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
8. [The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
9. [Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
11. [Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
12. [The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
13. [FBI-1 functions as a novel AR co-repressor in prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
14. [Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
15. [The functional interactome landscape of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
16. [DACH1 inhibits transforming growth factor-beta signaling through binding Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
17. [Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
18. [Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
19. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
20. [Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
21. [Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
22. [A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
23. [A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
24. [Huntingtin interacting proteins are genetic modifiers of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
25. [A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
26. [A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
27. [Enhancer activation requires trans-recruitment of a mega transcription factor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
28. [Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
29. [SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
30. [Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor  /  Agonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
31. [Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
32. [Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
33. [HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
35. [Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
36. [The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
37. [The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
38. [Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
39. [Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
40. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
41. [HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
42. [Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
43. [Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
44. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
45. [SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
46. [MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376)
47. [MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376)
48. Ensembl Release 99
49. UMLS 2023