# Nuclear receptor coactivator 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3681842](https://www.wikidata.org/wiki/Q3681842)  
**Source**: https://4ort.xyz/entity/nuclear-receptor-coactivator-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15788)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
6. [Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
7. [BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
8. [Negative modulation of androgen receptor transcriptional activity by Daxx](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
9. [Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
10. [Molecular determinants of the estrogen receptor-coactivator interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
11. [2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
12. [The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
13. [Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
14. [The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
15. [Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
16. [The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
17. [MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
18. [The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
19. [Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
20. [Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
21. [The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
22. [Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
23. [A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
24. [P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
25. [Molecular determinants of the interactions between SRC‐1 and LXR/RXR heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
26. [Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
27. [GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
28. [Synergism Between ERα Transactivation Function 1 (AF-1) and AF-2 Mediated by Steroid Receptor Coactivator Protein-1: Requirement for the AF-1 α-Helical Core and for a Direct Interaction Between the N- and C-Terminal Domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
29. [Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
30. [In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
31. [Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
32. [T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
33. [Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
34. [Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
35. [PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
36. [SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
37. [The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
38. [Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
40. [Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
41. [The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
42. [Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
43. [Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
44. [ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
45. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
46. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15788&geneProductId=UniProtKB:Q15788)
47. [Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
48. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
49. [Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)
50. [ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788)