Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Ankyrin repeat-containing domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Ankyrin repeat-containing domain, protein family
additional property: PropertyValue
  property ID: P361
  value: Ankyrin repeat, protein family
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat-containing domain
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat
additional property: PropertyValue
  property ID: P637
  value: NP_035037
additional property: PropertyValue
  property ID: P680
  value: NF-kappaB binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: nuclear localization sequence binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: response to muscle stretch
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein metabolic process
additional property: PropertyValue
  property ID: P682
  value: toll-like receptor 4 signaling pathway
additional property: PropertyValue
  property ID: P702
  value: Nfkbia
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000021413
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 29
      unique citations norm: 0.011
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 29
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9Z1E3
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797869
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat-containing domain superfamily
  P361:
    value: Q83146468
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat-containing domain, protein family
  P361:
    value: Q95353759
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat, protein family
  P527:
    value: Q24778891
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat-containing domain
  P527:
    value: Q24784174
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat
  P637:
    value: NP_035037
    source count: 1
    confidence: 0.2
  P680:
    value: Q14865606
    source count: 2
    confidence: 0.4
    value label: NF-kappaB binding
  P680:
    value: Q167149
    source count: 12
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q15325070
    source count: 2
    confidence: 0.4
    value label: nuclear localization sequence binding
  P680:
    value: Q14762994
    source count: 2
    confidence: 0.4
    value label: identical protein binding
  P680:
    value: Q14599289
    source count: 2
    confidence: 0.4
    value label: enzyme binding
  P681:
    value: Q79899
    source count: 5
    confidence: 1.0
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 3
    confidence: 0.6
    value label: cytosol
  P681:
    value: Q29548
    source count: 2
    confidence: 0.4
    value label: plasma membrane
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus
  P681:
    value: Q3824358
    source count: 2
    confidence: 0.4
    value label: intracellular anatomical structure
  P682:
    value: Q21095369
    source count: 1
    confidence: 0.2
    value label: response to muscle stretch
  P682:
    value: Q14758925
    source count: 2
    confidence: 0.4
    value label: positive regulation of protein metabolic process
  P682:
    value: Q14864554
    source count: 1
    confidence: 0.2
    value label: toll-like receptor 4 signaling pathway
  P682:
    value: Q14866222
    source count: 1
    confidence: 0.2
    value label: response to exogenous dsRNA
  P682:
    value: Q14914559
    source count: 2
    confidence: 0.4
    value label: cytoplasmic sequestering of transcription factor
  P702:
    value: Q15325111
    source count: 1
    confidence: 0.2
    value label: Nfkbia

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000021413
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB
stated in qid: Q28593482
retrieved: 2019-02-14

source: Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IκBα
stated in qid: Q24317303
retrieved: 2019-02-14

source: The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression
stated in qid: Q28585698
retrieved: 2019-02-14

source: Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).
stated in qid: Q30496086
retrieved: 2019-02-14

source: Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
stated in qid: Q28511500
retrieved: 2019-02-14

source: Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer
stated in qid: Q24307883
retrieved: 2019-02-14

source: A fourth IkappaB protein within the NF-kappaB signaling module
stated in qid: Q24676472
retrieved: 2019-02-14

source: Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function
stated in qid: Q28508365
retrieved: 2019-02-14

source: NF-kappaB dictates the degradation pathway of IkappaBalpha
stated in qid: Q28588231
retrieved: 2019-02-14

source: Bioinformatics and cellular signaling
stated in qid: Q28506971
retrieved: 2019-02-14

source: Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
stated in qid: Q28585900
retrieved: 2019-02-14

source: IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response
stated in qid: Q34158461
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-06-05

source: The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
stated in qid: Q28505401
retrieved: 2019-02-14

source: JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
stated in qid: Q28567187
retrieved: 2019-02-14

source: Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch
stated in qid: Q28588382
retrieved: 2019-02-14

source: The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
stated in qid: Q28512240
retrieved: 2019-02-14

source: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
stated in qid: Q28587545
retrieved: 2019-02-14

source: JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
stated in qid: Q28567187
retrieved: 2018-06-05

source: Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
stated in qid: Q28587612
retrieved: 2019-02-14

source: Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm
stated in qid: Q28589141
retrieved: 2019-02-14

source: Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells
stated in qid: Q28587448
retrieved: 2019-02-14

source: Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
stated in qid: Q28504578
retrieved: 2019-02-14

source: MicroRNA-494, Upregulated by Tumor Necrosis Factor-α, Desensitizes Insulin Effect in C2C12 Muscle Cells
stated in qid: Q35070980
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q15325126
domain: protein
level: standard
html url: https://4ort.xyz/entity/nuclear-factor-of-kappa-light-polypeptide-gene-enhancer-in-b-cells-inhibitor-alpha
markdown url: https://4ort.xyz/entity/nuclear-factor-of-kappa-light-polypeptide-gene-enhancer-in-b-cells-inhibitor-alpha.md
facts url summary: https://4ort.xyz/entity/nuclear-factor-of-kappa-light-polypeptide-gene-enhancer-in-b-cells-inhibitor-alpha/facts.json
facts url standard: https://4ort.xyz/entity/nuclear-factor-of-kappa-light-polypeptide-gene-enhancer-in-b-cells-inhibitor-alpha/facts.json
facts url full: https://4ort.xyz/entity/nuclear-factor-of-kappa-light-polypeptide-gene-enhancer-in-b-cells-inhibitor-alpha/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T00:32:01.124373Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:55:41.458975+00:00Z