Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: scramjet
additional property: PropertyValue
  property ID: P361
  value: p53-like transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Nuclear factor of activated T cells (NFAT)
additional property: PropertyValue
  property ID: P527
  value: Rel homology dimerisation domain
additional property: PropertyValue
  property ID: P527
  value: IPT domain
additional property: PropertyValue
  property ID: P527
  value: Rel homology domain (RHD), DNA-binding domain
additional property: PropertyValue
  property ID: P637
  value: NP_001032254
additional property: PropertyValue
  property ID: P637
  value: NP_001032255
additional property: PropertyValue
  property ID: P637
  value: NP_001129545
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: sequence-specific DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription factor activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: transcription regulator complex
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P682
  value: B cell receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: cytokine production
additional property: PropertyValue
  property ID: P702
  value: Nfatc2
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000074198
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000104812
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000029057
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 49
      unique citations norm: 0.019
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 49
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q60591
    source count: 1
    confidence: 0.2
    value label: scramjet
  P361:
    value: Q24769358
    source count: 1
    confidence: 0.2
    value label: p53-like transcription factor, DNA-binding
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q24744925
    source count: 1
    confidence: 0.2
    value label: Nuclear factor of activated T cells (NFAT)
  P361:
    value: Q41798150
    source count: 1
    confidence: 0.2
    value label: Rel homology domain (RHD), DNA-binding domain superfamily
  P361:
    value: Q24780081
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin E-set
  P527:
    value: Q24771472
    source count: 1
    confidence: 0.2
    value label: Rel homology dimerisation domain
  P527:
    value: Q24770513
    source count: 1
    confidence: 0.2
    value label: IPT domain
  P527:
    value: Q24722412
    source count: 1
    confidence: 0.2
    value label: Rel homology domain (RHD), DNA-binding domain
  P637:
    value: NP_001032254
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001032255
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001129545
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001278097
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001278098
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q14818107
    source count: 2
    confidence: 0.4
    value label: sequence-specific DNA binding
  P680:
    value: Q14817979
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription factor activity
  P680:
    value: Q14817973
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P680:
    value: Q14817982
    source count: 1
    confidence: 0.2
    value label: transcription factor binding
  P681:
    value: Q79899
    source count: 8
    confidence: 1.0
    value label: cytoplasm

value: Q14818102
source count: 1
confidence: 0.2
value label: transcription regulator complex

value: Q14817956
source count: 3
confidence: 0.6
value label: nucleoplasm

value: Q40260
source count: 11
confidence: 1.0
value label: nucleus

value: Q220599
source count: 5
confidence: 1.0
value label: cytosol

value: Q14863427
source count: 2
confidence: 0.4
value label: B cell receptor signaling pathway

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q14865389
source count: 1
confidence: 0.2
value label: cytokine production

value: Q14905251
source count: 1
confidence: 0.2
value label: calcineurin-NFAT signaling cascade

value: Q14633878
source count: 1
confidence: 0.2
value label: negative regulation of transcription by RNA polymerase II

value: Q18252616
source count: 1
confidence: 0.2
value label: Nfatc2

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000074198
source count: 1
confidence: 0.2

value: ENSMUSP00000104812
source count: 1
confidence: 0.2

value: ENSMUSP00000029057
source count: 1
confidence: 0.2

value: ENSMUSP00000118329
source count: 1
confidence: 0.2

value: ENSMUSP00000130875
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
stated in qid: Q24322959
retrieved: 2019-02-14

source: NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity
stated in qid: Q28591436
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-06-21

source: Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
stated in qid: Q28591453
retrieved: 2018-06-21

source: Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
stated in qid: Q28511815
retrieved: 2018-09-10

source: Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
stated in qid: Q28511815
retrieved: 2019-02-14

source: A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
stated in qid: Q28588110
retrieved: 2018-06-21

source: NFATc2-mediated repression of cyclin-dependent kinase 4 expression
stated in qid: Q28505899
retrieved: 2018-06-21

source: Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain
stated in qid: Q28585949
retrieved: 2018-06-21

source: Sequential involvement of NFAT and Egr transcription factors in FasL regulation
stated in qid: Q28507094
retrieved: 2018-06-21

source: NFATc2-mediated repression of cyclin-dependent kinase 4 expression
stated in qid: Q28505899
retrieved: 2019-02-14

source: Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet
stated in qid: Q41791634
retrieved: 2019-02-14

source: NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins
stated in qid: Q27649708
retrieved: 2019-02-14

source: The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
stated in qid: Q48257104
retrieved: 2019-02-14

source: An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
stated in qid: Q28504786
retrieved: 2019-02-14

source: Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2
stated in qid: Q24302043
retrieved: 2019-02-14

source: Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure
stated in qid: Q28118235
retrieved: 2019-02-14

source: Sequential involvement of NFAT and Egr transcription factors in FasL regulation
stated in qid: Q28507094
retrieved: 2019-02-14

source: Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
stated in qid: Q28591453
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
stated in qid: Q28588110
retrieved: 2019-02-14

source: Defective T cell development and function in calcineurin A beta -deficient mice
stated in qid: Q28592115
retrieved: 2019-02-14

source: Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
stated in qid: Q28505989
retrieved: 2019-02-14

source: Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
stated in qid: Q24323167
retrieved: 2019-02-14

source: Dynamic response diversity of NFAT isoforms in individual living cells
stated in qid: Q28507712
retrieved: 2019-02-14

source: Mina, an Il4 repressor, controls T helper type 2 bias
stated in qid: Q28511123
retrieved: 2018-06-21

source: An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
stated in qid: Q28504786
retrieved: 2018-06-21

source: Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos
stated in qid: Q28590370
retrieved: 2018-06-21

source: Calcium/NFAT signalling promotes early nephrogenesis
stated in qid: Q28505430
retrieved: 2018-06-21

wikidata id: Q21987765
domain: protein
level: standard
html url: https://4ort.xyz/entity/nuclear-factor-of-activated-t-cells-cytoplasmic-calcineurin-dependent-2
markdown url: https://4ort.xyz/entity/nuclear-factor-of-activated-t-cells-cytoplasmic-calcineurin-dependent-2.md
facts url summary: https://4ort.xyz/entity/nuclear-factor-of-activated-t-cells-cytoplasmic-calcineurin-dependent-2/facts.json
facts url standard: https://4ort.xyz/entity/nuclear-factor-of-activated-t-cells-cytoplasmic-calcineurin-dependent-2/facts.json
facts url full: https://4ort.xyz/entity/nuclear-factor-of-activated-t-cells-cytoplasmic-calcineurin-dependent-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T16:28:10.857289Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:33.893913+00:00Z