# Nuclear factor, erythroid derived 2,-like 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21496622](https://www.wikidata.org/wiki/Q21496622)  
**Source**: https://4ort.xyz/entity/nuclear-factor-erythroid-derived-2-like-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61985)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
5. [Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
7. [Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
8. [Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
9. [Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
10. [Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
11. [NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
12. [TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
13. [The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
14. [NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
15. [Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
16. [The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
17. [NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
19. [Induction of Herpud1 expression by ER stress is regulated by Nrf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
20. [p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
21. [Characterization of Nrf1b, a Novel Isoform of the Nuclear Factor-Erythroid-2 Related Transcription Factor-1 That Activates Antioxidant Response Element-Regulated Genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985)
22. [Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
23. [The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
24. [Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
25. [Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
26. [Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
27. [Nuclear factor‐erythroid 2‐related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
28. [A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
29. [Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
30. [Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
31. [Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
32. [Expression profiling of Aldh1l1‐precursors in the developing spinal cord reveals glial lineage‐specific genes and direct Sox9‐Nfe2l1 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985)
33. ensembl Release 106