# Nuclear factor, erythroid 2 like 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21119871](https://www.wikidata.org/wiki/Q21119871)  
**Source**: https://4ort.xyz/entity/nuclear-factor-erythroid-2-like-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16236)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
5. [Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
6. [Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
7. [Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
9. [DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
10. [The role of oxidative stress in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
11. [Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
12. [DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
13. [Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
14. [Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
15. [Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
16. [The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
17. [Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
18. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
19. [Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
20. [A protein domain-based interactome network for C. elegans early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
21. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
23. [The role of oxidative stress in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
25. [Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
26. [DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
27. [Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
28. [Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
29. [Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
30. [HO-1 underlies resistance of AML cells to TNF-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
31. [DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
32. [HO-1 underlies resistance of AML cells to TNF-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
33. [Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
34. [Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
35. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
36. [Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
37. [Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
38. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
39. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236)
40. [Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis via Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
41. [Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
42. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236)
43. Ensembl Release 99