# NPC intracellular cholesterol transporter 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q22678624](https://www.wikidata.org/wiki/Q22678624)  
**Source**: https://4ort.xyz/entity/npc-intracellular-cholesterol-transporter-2


## References

1. UniProt
2. Q20641742
3. [In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
5. [Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
6. [NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
7. [NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
8. [Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
9. [Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
10. [The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
12. [Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
13. [Identification of HE1 as the second gene of Niemann-Pick C disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
14. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
15. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
17. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
18. [Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
19. [NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
20. [Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
21. [Regulation of sterol transport between membranes and NPC2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
22. [NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916)
23. [Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
24. [Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
25. [Regulation of sterol transport between membranes and NPC2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
26. [NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916)
27. Ensembl Release 99
28. Transporter Classification database