# NPC intracellular cholesterol transporter 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6748237](https://www.wikidata.org/wiki/Q6748237)  
**Source**: https://4ort.xyz/entity/npc-intracellular-cholesterol-transporter-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15118)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
6. [Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
7. [NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
8. [Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
9. [Identification of cholesterol-regulating genes by targeted RNAi screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
10. [Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
11. [The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
12. [Mutations in NPC1 highlight a conserved NPC1-specific cysteine-rich domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
13. [Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
14. [Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118)
16. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118)
17. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
18. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118)
19. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118)
20. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
21. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
22. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
23. [3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
24. [Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
25. [Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
26. [Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
27. [Ebola virus entry requires the cholesterol transporter Niemann-Pick C1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
28. [Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
29. [NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118)
30. [Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
31. [NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118)
32. Ensembl Release 99
33. Transporter Classification database