# NPC intracellular cholesterol transporter 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14914281](https://www.wikidata.org/wiki/Q14914281)  
**Source**: https://4ort.xyz/entity/npc-intracellular-cholesterol-transporter-1-q14914281


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O35604)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
5. [Niemann–Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
6. [Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
7. [Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
8. [A molecular mechanism underlying the neural-specific defect in torsinA mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
9. [Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35604&geneProductId=UniProtKB:O35604)
11. [Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
12. [Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
13. [Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
14. [Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
15. [Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
16. [Ebola virus entry requires the cholesterol transporter Niemann-Pick C1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604)
17. ensembl Release 106