# Notch receptor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21124891](https://www.wikidata.org/wiki/Q21124891)  
**Source**: https://4ort.xyz/entity/notch-receptor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q04721)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
5. [C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
6. [MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
7. [Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
8. [Human ligands of the Notch receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
9. [Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
10. [MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
11. [NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
12. [Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
13. [Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721)
15. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721)
16. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
17. [Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
18. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
20. [Notch signaling induces cell cycle arrest in small cell lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
21. [NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
22. [Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721)
23. [Notch2 protein distribution in human teeth under normal and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
24. [Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
25. [Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
26. [Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721)
27. ensembl Release 95
28. UMLS 2023