# Notch receptor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4044985](https://www.wikidata.org/wiki/Q4044985)  
**Source**: https://4ort.xyz/entity/notch-receptor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46531)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
5. [The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
6. [MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
7. [A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
8. [Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
9. [Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
10. [SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
11. [NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
12. [Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
13. [The CD46-Jagged1 interaction is critical for human TH1 immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
14. [Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
15. [The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
16. [Notch signaling mediates hypoxia-induced tumor cell migration and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
17. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
18. [NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
19. [Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
20. [Direct inhibition of the NOTCH transcription factor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
21. [Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
22. [Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
23. [Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
24. [Notch is a direct negative regulator of the DNA-damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
25. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
26. [Notch1 augments NF-kappaB activity by facilitating its nuclear retention](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
27. [Cyclin C is a haploinsufficient tumour suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
28. [Ataxin‐1 and Brother of ataxin‐1 are components of the Notch signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
29. [Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
30. [A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
31. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
34. [Mutations in NOTCH1 cause aortic valve disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531)
35. [Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531)
36. [Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
37. [Notch signaling induces cell cycle arrest in small cell lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
38. [Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
39. [Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
40. [Mutations in NOTCH1 cause aortic valve disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
41. [Identification of de novo mutations and rare variants in hypoplastic left heart syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
42. [Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
43. [Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
44. [TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
45. [Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
46. [Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
47. [NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
48. [NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
49. [Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531)
50. Ensembl Release 99