# Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

> Research article (Nature Methods, 2020) · cited 1,836× · AI/ML

**Wikidata**: [openalex:W3108495343](https://www.wikidata.org/wiki/openalex:W3108495343)  
**Source**: https://4ort.xyz/entity/non-uniform-refinement-adaptive-regularization-improves-single-particle-cryo-em-reconstruction