# Noggin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7047475](https://www.wikidata.org/wiki/Q7047475)  
**Source**: https://4ort.xyz/entity/noggin-q7047475


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13253)
3. Q20641742
4. [Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
5. [New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
6. [A GDF5 point mutation strikes twice--causing BDA1 and SYNS2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
7. [The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
8. [The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
10. [Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
12. [Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
13. [Identification of mammalian noggin and its expression in the adult nervous system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
14. [Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
15. [Identification of mammalian noggin and its expression in the adult nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
17. [Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
18. [Bone morphogenetic protein antagonist gene NOG is involved in myeloproliferative disease associated with myelofibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
19. [Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
20. [CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
21. [Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
22. [Skeletal overexpression of gremlin impairs bone formation and causes osteopenia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
23. [The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253)
24. [Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
25. [Skeletal overexpression of gremlin impairs bone formation and causes osteopenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253)
26. Ensembl Release 99