Nodal growth differentiation factor
type: Thing
alternate name: NODAL
alternate name: nodal homolog
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Transforming growth factor-beta-related
additional property: PropertyValue
  property ID: P361
  value: Cystine-knot cytokine
additional property: PropertyValue
  property ID: P361
  value: Transforming growth factor-beta, C-terminal domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Transforming growth factor-beta, C-terminal
additional property: PropertyValue
  property ID: P527
  value: Transforming growth factor beta, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_001316835
additional property: PropertyValue
  property ID: P637
  value: NP_060525
additional property: PropertyValue
  property ID: P637
  value: XP_024303796
additional property: PropertyValue
  property ID: P638
  value: 4N1D
additional property: PropertyValue
  property ID: P646
  value: /m/03g__g2
additional property: PropertyValue
  property ID: P680
  value: receptor ligand activity
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P680
  value: type I activin receptor binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P682
  value: trophectodermal cellular morphogenesis
additional property: PropertyValue
  property ID: P682
  value: left lung morphogenesis
additional property: PropertyValue
  property ID: P682
  value: nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
additional property: PropertyValue
  property ID: P702
  value: NODAL
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000287139
additional property: PropertyValue
  property ID: P705
  value: ENSP00000394468
additional property: PropertyValue
  property ID: P1889
  value: Transmission control room
additional property: PropertyValue
  property ID: P6366
  value: 83330619
additional property: PropertyValue
  property ID: P6366
  value: 2911142942
additional property: PropertyValue
  property ID: P10283
  value: C83330619
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 5
      sitelinks norm: 0.012
      unique citations: 18
      unique citations norm: 0.007
      monthly pageviews: 12
      monthly pageviews norm: 0.0
  sitelinks: 5
  unique citations: 18
  monthly pageviews: 12
  yearly pageviews: 49
  pageview trend:
    m: 2026-08
    v: 12
  pageview trend:
    m: 2026-07
    v: 1
  pageview trend:
    m: 2026-06
    v: 8
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-05
    v: 3
  pageview trend:
    m: 2026-05
    v: 2
  pageview trend:
    m: 2026-04
    v: 1
  pageview trend:
    m: 2026-04
    v: 21
  popularity:
    sitelinks: 5
    max: 423
    pct: 1.2
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q96S42
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724932
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta-related
  P361:
    value: Q24783539
    source count: 1
    confidence: 0.2
    value label: Cystine-knot cytokine
  P361:
    value: Q83133008
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta, C-terminal domain, protein family
  P361:
    value: Q95353195
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor beta, conserved site, protein family
  P527:
    value: Q24721300
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta, C-terminal
  P527:
    value: Q24725603
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor beta, conserved site
  P637:
    value: NP_001316835
    source count: 1
    confidence: 0.2
  P637:
    value: NP_060525
    source count: 1
    confidence: 0.2
  P637:
    value: XP_024303796
    source count: 1
    confidence: 0.2
  P638:
    value: 4N1D
    source count: 1
    confidence: 0.2
  P646:
    value: /m/03g__g2
    source count: 0
    confidence: 0.0
  P680:
    value: Q14907861
    source count: 1
    confidence: 0.2
    value label: receptor ligand activity
  P680:
    value: Q14862699
    source count: 2
    confidence: 0.4
    value label: cytokine activity

value: Q14904333
source count: 1
confidence: 0.2
value label: type I activin receptor binding

value: Q14859905
source count: 1
confidence: 0.2
value label: morphogen activity

value: Q14903935
source count: 1
confidence: 0.2
value label: transforming growth factor beta receptor binding

value: Q14645596
source count: 2
confidence: 0.4
value label: extracellular region

value: Q1385443
source count: 2
confidence: 0.4
value label: extracellular space

value: Q1385443
source count: 3
confidence: 0.6
value label: extracellular space

value: Q21111151
source count: 1
confidence: 0.2
value label: trophectodermal cellular morphogenesis

value: Q14908079
source count: 1
confidence: 0.2
value label: left lung morphogenesis

value: Q21097187
source count: 1
confidence: 0.2
value label: nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

value: Q14901645
source count: 1
confidence: 0.2
value label: neural fold formation

value: Q14885639
source count: 1
confidence: 0.2
value label: maternal process involved in parturition

value: Q18030174
source count: 1
confidence: 0.2
value label: NODAL

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000287139
source count: 1
confidence: 0.2

value: ENSP00000394468
source count: 1
confidence: 0.2

value: Q7834636
source count: 0
confidence: 0.0
value label: Transmission control room

value: 83330619
source count: 0
confidence: 0.0

value: 2911142942
source count: 0
confidence: 0.0

value: C83330619
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia
stated in qid: Q24294289
retrieved: 2018-04-24

source: Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype
stated in qid: Q24316417
retrieved: 2019-04-08

source: Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia
stated in qid: Q24294289
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells
stated in qid: Q24306210
retrieved: 2018-04-24

source: Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells
stated in qid: Q24306210
retrieved: 2019-04-08

source: Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
stated in qid: Q24312034
retrieved: 2019-04-08

source: Inhibition of Nodal suppresses angiogenesis and growth of human gliomas
stated in qid: Q24309876
retrieved: 2019-04-08

source: Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
stated in qid: Q24312034
retrieved: 2018-04-24

source: Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
stated in qid: Q24305109
retrieved: 2019-04-08

source: Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells
stated in qid: Q24293592
retrieved: 2019-04-08

source: OpenAlex
stated in qid: Q107507571
retrieved: 2022-01-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21124872
domain: protein
level: standard
html url: https://4ort.xyz/entity/nodal-growth-differentiation-factor
markdown url: https://4ort.xyz/entity/nodal-growth-differentiation-factor.md
facts url summary: https://4ort.xyz/entity/nodal-growth-differentiation-factor/facts.json
facts url standard: https://4ort.xyz/entity/nodal-growth-differentiation-factor/facts.json
facts url full: https://4ort.xyz/entity/nodal-growth-differentiation-factor/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T09:15:57.032759Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:26:35.220129+00:00Z