# NLR family pyrin domain containing 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4044963](https://www.wikidata.org/wiki/Q4044963)  
**Source**: https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-3-q4044963


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96P20)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
5. [GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
6. [The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
7. [Novel role of PKR in inflammasome activation and HMGB1 release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
8. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
9. [The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
10. [AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
11. [Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
12. [The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
13. [NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
14. [Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
15. [PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
16. [NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
17. [Evaluation of Nod-like receptor (NLR) effector domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
18. [NLRs join TLRs as innate sensors of pathogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
19. [Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
20. [Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20)
21. [Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20)
23. [Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
24. [NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20)
25. [A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
26. [NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
27. [Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
28. [De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
29. [Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
30. [Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
31. [De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20)
32. [Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
33. [PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
34. [Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20)
36. Ensembl Release 99
37. UMLS 2023