# NLR family pyrin domain containing 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21171805](https://www.wikidata.org/wiki/Q21171805)  
**Source**: https://4ort.xyz/entity/nlr-family-pyrin-domain-containing-1


## References

1. UniProt
2. Q20641742
3. [The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
5. [Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
6. [Expression of NALP1 in cerebellar granule neurons stimulates apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
7. [Novel role of PKR in inflammasome activation and HMGB1 release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
8. [CLAN, a novel human CED-4-like gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
9. [Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
10. [A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
11. [Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
12. [Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
13. [Evaluation of Nod-like receptor (NLR) effector domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C000&geneProductId=UniProtKB:Q9C000)
15. [Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
16. [Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C000&geneProductId=UniProtKB:Q9C000)
17. [The inflammasomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
18. [The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
20. [Expression of NALP1 in cerebellar granule neurons stimulates apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C000&geneProductId=UniProtKB:Q9C000)
21. [Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C000)
22. Ensembl Release 99