# NK2 homeobox 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21123095](https://www.wikidata.org/wiki/Q21123095)  
**Source**: https://4ort.xyz/entity/nk2-homeobox-5


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P52952)
3. Q20641742
4. [Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
6. [Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
7. [Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
8. [The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
9. [Common arterial trunk associated with a homeodomain mutation of NKX2.6](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
10. [Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
11. [Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
13. [Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
14. [The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
15. [Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
16. [Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
17. [Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
18. [The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
19. [Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
20. [miR-145 and miR-143 regulate smooth muscle cell fate and plasticity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
21. [Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
22. [Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
23. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
24. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
25. [Common arterial trunk associated with a homeodomain mutation of NKX2.6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
26. [miR-145 and miR-143 regulate smooth muscle cell fate and plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
27. [Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
29. [Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
30. [Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
31. [Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
32. [Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
33. [Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
34. [New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
35. [Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
36. [CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
37. [Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
38. [NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
39. [Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
40. [Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
41. [NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
42. [MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
43. [Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
44. [The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52952&geneProductId=UniProtKB:P52952)
45. [MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
46. [Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52952)
47. Ensembl Release 99