# NK2 homeobox 5

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984774](https://www.wikidata.org/wiki/Q21984774)  
**Source**: https://4ort.xyz/entity/nk2-homeobox-5-q21984774


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42582)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
5. [A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
6. [Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
7. [A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
9. [Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
10. [The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
11. [A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
12. [Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
13. [GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
14. [Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
15. [UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
16. [UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
17. [A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
18. [Foxh1 is essential for development of the anterior heart field](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
19. [The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
20. [The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
21. [Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
22. [Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
23. [Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
24. [Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
25. [Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
26. [Hop is an unusual homeobox gene that modulates cardiac development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
27. [Csm, a Cardiac-specific Isoform of the RNA Helicase Mov10l1, Is Regulated by Nkx2.5 in Embryonic Heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
28. [miR-145 and miR-143 regulate smooth muscle cell fate and plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
29. [Foxh1 is essential for development of the anterior heart field](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
30. [The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
31. [The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
33. [A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
34. [CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
35. [Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
36. [Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
37. [Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
38. [CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42582&geneProductId=UniProtKB:P42582)
39. [Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
40. [Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
41. [Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
42. [Vertebrate homologs oftinman andbagpipe: Roles of the homeobox genes in cardiovascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
43. [A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
44. [Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
45. [Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
46. [Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
47. [The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
48. [Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
49. [Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)
50. [Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42582)