# NK2 homeobox 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987285](https://www.wikidata.org/wiki/Q21987285)  
**Source**: https://4ort.xyz/entity/nk2-homeobox-2-q21987285


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42586)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
5. [Conserved Transcriptional Regulatory Domains of the pdx-1 Gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
7. [Cross-Repressive Interaction of the Olig2 and Nkx2.2 Transcription Factors in Developing Neural Tube Associated with Formation of a Specific Physical Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
8. [Nkx2.2-repressor activity is sufficient to specify α-cells and a small number of β-cells in the pancreatic islet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
9. [Cooperative Transcriptional Regulation of the Essential Pancreatic Islet Gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
10. [Cross-Repressive Interaction of the Olig2 and Nkx2.2 Transcription Factors in Developing Neural Tube Associated with Formation of a Specific Physical Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
11. [Gata6 is an important regulator of mouse pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
13. [Conserved Transcriptional Regulatory Domains of the pdx-1 Gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
14. [Neuronatin, a Downstream Target of BETA2/NeuroD1 in the Pancreas, Is Involved in Glucose-Mediated Insulin Secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
15. [Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
16. [The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
17. [The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
18. [Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
19. [The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
20. [The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
21. [Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
22. [A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
23. [Ascl1 is required for oligodendrocyte development in the spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
24. [Nkx2.2 Regulates β-Cell Function in the Mature Islet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
25. [Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
26. [A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
27. [Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
28. [Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
29. [MicroRNA-23a promotes myelination in the central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
30. [Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
31. [Genetic identification of a novel NeuroD1 function in the early differentiation of islet α, PP and ε cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
32. [Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586)
33. [Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
34. [Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
35. [The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
36. [FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
37. [Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
38. [Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586)
39. ensembl Release 106