# NK2 homeobox 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109009](https://www.wikidata.org/wiki/Q21109009)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/NK2_homeobox_1)  
**Source**: https://4ort.xyz/entity/nk2-homeobox-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43699)
3. Q20641742
4. [Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
7. [TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
8. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
9. [BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
10. [A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
11. [Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
12. [A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
13. [Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
14. [Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
15. [Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
16. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
17. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
19. [A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
20. [Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
21. [Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
22. [Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
23. [Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43699&geneProductId=UniProtKB:P43699)
24. [Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
25. [Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
26. [PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
27. [Mutations in TITF-1 are associated with benign hereditary chorea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
28. [Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
29. [NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43699)
30. Ensembl Release 99
31. UMLS 2023
32. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)