# NK2 homeobox 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987288](https://www.wikidata.org/wiki/Q21987288)  
**Source**: https://4ort.xyz/entity/nk2-homeobox-1-q21987288


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P50220)
3. Q20641742
4. [TAZ interacts with TTF-1 and regulates expression of surfactant protein-C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
5. [GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
6. [CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
7. [The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
8. [Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
9. [TTF-1/NKX2.1 up-regulates the in vivo transcription of nestin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
12. [The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
13. [Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
14. [Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
15. [The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
16. [GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
17. [Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
18. [GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
19. [Thyroid Transcription Factor 1, a Homeodomain Containing Transcription Factor, Contributes to Regulating Periodic Oscillations in GnRH Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
20. [Thyroid Transcription Factor 1, a Homeodomain Containing Transcription Factor, Contributes to Regulating Periodic Oscillations in GnRH Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
21. [TTF-1/NKX2.1 up-regulates the in vivo transcription of nestin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
22. [Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
24. [Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
25. [GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
26. [The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
27. [TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
28. [Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
29. [Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
30. [Calcineurin/Nfat signaling is required for perinatal lung maturation and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
31. [Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
32. [TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
33. [Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
34. [The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
35. [Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
36. [Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
37. [Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50220&geneProductId=UniProtKB:P50220)
38. [Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
39. [The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
40. [TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
41. [Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
42. [Calcineurin/Nfat signaling is required for perinatal lung maturation and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
43. [TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
44. [Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
45. [Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
46. [Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
47. [Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
48. [The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
49. [Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)
50. [Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50220)