# Nitric oxide synthase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q408853](https://www.wikidata.org/wiki/Q408853)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Endothelial_NOS)  
**Source**: https://4ort.xyz/entity/nitric-oxide-synthase-3


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
7. [beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
9. [Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
10. [NOSIP, a novel modulator of endothelial nitric oxide synthase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
11. [LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
12. [Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
13. [Endothelial cell expression of haemoglobin α regulates nitric oxide signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
14. [Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
15. [Interactome mapping suggests new mechanistic details underlying Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
16. [NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
18. [Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
19. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
20. [Nitric oxide regulates endocytosis by S-nitrosylation of dynamin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
21. [NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
22. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
23. [Caveolae and caveolin-1 in human term villous trophoblast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
24. [Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
25. [Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
26. [Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
29. [Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
30. [Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
31. [Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
32. [Thrombin receptor activation inhibits monocyte spreading by induction of ET(B) receptor-coupled nitric oxide release](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
33. [Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
34. [Thrombin receptor activation inhibits monocyte spreading by induction of ET(B) receptor-coupled nitric oxide release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
35. [C. pneumoniaedisrupts eNOS trafficking and impairs NO production in human aortic endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
36. [beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474)
37. [Permissive role of nitric oxide in endothelin-induced migration of endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
38. [Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
39. [Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
40. [The L-arginine-nitric oxide pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
41. [MiR-492 impairs the angiogenic potential of endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
42. [Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474)
43. Ensembl Release 99
44. Identifiers.org
45. UMLS 2023
46. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)