# Nicastrin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7024546](https://www.wikidata.org/wiki/Q7024546)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Nicastrin)  
**Source**: https://4ort.xyz/entity/nicastrin


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1090771)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL463981)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1770916)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92542)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
8. [Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
9. [Cellular localization of Nicastrin affects amyloid beta species production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
10. [An atomic structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
11. [Intracellular trafficking of TREM2 is regulated by presenilin 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
12. [TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
13. [An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
16. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
17. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
18. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
19. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
20. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
21. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
22. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
23. [Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
24. [Three-dimensional structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
25. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
27. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
28. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
29. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
30. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
31. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542)
32. [An atomic structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
33. [Three-dimensional structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542)
34. Ensembl Release 99
35. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)