# Nicastrin

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911609](https://www.wikidata.org/wiki/Q14911609)  
**Source**: https://4ort.xyz/entity/nicastrin-q14911609


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P57716)
3. Q20641742
4. [Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716)
5. [Inhibitors of γ‐secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
6. [Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
7. [ER-stress-inducible Herp, facilitates the degradation of immature nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
8. [Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
9. [An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716)
12. [Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
13. [Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716)
16. [Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716)
17. [Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716)
18. [Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
19. [Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
20. [Spatial segregation of gamma-secretase and substrates in distinct membrane domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
21. [Presenilin 1 is required for maturation and cell surface accumulation of nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
22. [APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
23. [An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
24. [Cellular localization of Nicastrin affects amyloid beta species production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
25. [Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
26. [Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
27. [Synaptic function of nicastrin in hippocampal neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
28. [Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
29. [Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716)
30. ensembl Release 106
31. Transporter Classification database