# Nibrin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q14911994](https://www.wikidata.org/wiki/Q14911994)  
**Source**: https://4ort.xyz/entity/nibrin-q14911994


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60934)
3. Q20641742
4. [The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
5. [ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934)
6. [Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
7. [Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
8. [N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
9. [MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
10. [ATRX dysfunction induces replication defects in primary mouse cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
11. [ATM-dependent phosphorylation of ATF2 is required for the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
12. [SOSS complexes participate in the maintenance of genomic stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
13. [PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
14. [A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
15. [RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
16. [Acetyltransferase p300 regulates NBS1-mediated DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
17. [MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
18. [A divalent FHA/BRCT‐binding mechanism couples the MRE11–RAD50–NBS1 complex to damaged chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
19. [MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
20. [MDC1 is a mediator of the mammalian DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
21. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
22. [Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
23. [The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
24. [CtIP tetramer assembly is required for DNA-end resection and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
25. [MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
26. [Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
27. [Five dysfunctional telomeres predict onset of senescence in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
28. [Notch is a direct negative regulator of the DNA-damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
29. [VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
30. [RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
31. [CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
32. [Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
33. [SIRT1 regulates the function of the Nijmegen breakage syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
34. [NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
35. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
36. [Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
38. [ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
39. [Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
40. [Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
41. [The mismatch repair system is required for S-phase checkpoint activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
42. [A balance between elongation and trimming regulates telomere stability in stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934)
43. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934)
44. [The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934)
45. [RAD50 and NBS1 form a stable complex functional in DNA binding and tethering](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934)
46. [A balance between elongation and trimming regulates telomere stability in stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
47. [RAD50 and NBS1 form a stable complex functional in DNA binding and tethering](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
48. [ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
49. [The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)
50. [Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934)