# NFKB inhibitor alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6103521](https://www.wikidata.org/wiki/Q6103521)  
**Source**: https://4ort.xyz/entity/nfkb-inhibitor-alpha-q6103521


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25963)
3. Q20641742
4. [Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
5. [Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
6. [In silico structural and functional characterization of the RSUME splice variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
7. [Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
8. [Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
9. [Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
10. [DDRGK1 Regulates NF-κB Activity by Modulating IκBα Stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
11. [Crystal structure of inhibitor of κB kinase β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
12. [NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
13. [Ribosomal protein S3 interacts with the NF-κB inhibitor IκBα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
14. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
15. [Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
16. [The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
17. [Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
18. [Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
19. [Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
20. [Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
21. [The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
22. [The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
23. [Structure of an IkappaBalpha/NF-kappaB complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
24. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
25. [Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
26. [Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
27. [Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
28. [NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
29. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
30. [Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
31. [HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
32. [α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
33. [The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
34. [A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
35. [betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
36. [CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
37. [Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
38. [IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
39. [Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
40. [Binding of manumycin A inhibits IkappaB kinase beta activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
41. [The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
42. [Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
43. [CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
44. [Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
45. [Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
46. [Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
47. [Krüppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
48. [A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
49. [NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)
50. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25963)