NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: Zalesie-Grzymały
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Moesin tail domain superfamily
additional property: PropertyValue
  property ID: P361
  value: FERM/acyl-CoA-binding protein superfamily
additional property: PropertyValue
  property ID: P527
  value: FERM domain
additional property: PropertyValue
  property ID: P527
  value: FERM, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Band 4.1 domain
additional property: PropertyValue
  property ID: P637
  value: NP_037325
additional property: PropertyValue
  property ID: P637
  value: XP_006251250
additional property: PropertyValue
  property ID: P637
  value: XP_006251253
additional property: PropertyValue
  property ID: P680
  value: actin binding
additional property: PropertyValue
  property ID: P680
  value: integrin binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoskeleton
additional property: PropertyValue
  property ID: P682
  value: negative regulation of cell growth
additional property: PropertyValue
  property ID: P682
  value: regulation of apoptotic process
additional property: PropertyValue
  property ID: P682
  value: regulation of cell cycle
additional property: PropertyValue
  property ID: P702
  value: Nf2
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000010690
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 12
      unique citations norm: 0.005
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 12
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q63648
    source count: 1
    confidence: 0.2
    value label: Zalesie-Grzymały
  P361:
    value: Q24725964
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-like domain superfamily
  P361:
    value: Q24771400
    source count: 1
    confidence: 0.2
    value label: Moesin tail domain superfamily
  P361:
    value: Q24722877
    source count: 1
    confidence: 0.2
    value label: FERM/acyl-CoA-binding protein superfamily
  P361:
    value: Q24786013
    source count: 1
    confidence: 0.2
    value label: PH-like domain superfamily
  P361:
    value: Q41797112
    source count: 1
    confidence: 0.2
    value label: FERM superfamily, second domain
  P527:
    value: Q24723028
    source count: 1
    confidence: 0.2
    value label: FERM domain
  P527:
    value: Q24726381
    source count: 1
    confidence: 0.2
    value label: FERM, N-terminal
  P527:
    value: Q24785866
    source count: 1
    confidence: 0.2
    value label: Band 4.1 domain
  P527:
    value: Q24771063
    source count: 1
    confidence: 0.2
    value label: FERM, C-terminal PH-like domain
  P527:
    value: Q24722510
    source count: 1
    confidence: 0.2
    value label: FERM central domain
  P637:
    value: NP_037325
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006251250
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006251253
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038947569
    source count: 1
    confidence: 0.2
  P680:
    value: Q14863962
    source count: 1
    confidence: 0.2
    value label: actin binding
  P680:
    value: Q14633861
    source count: 1
    confidence: 0.2
    value label: integrin binding
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q14872998
    source count: 1
    confidence: 0.2
    value label: beta-catenin binding
  P680:
    value: Q14864842
    source count: 1
    confidence: 0.2
    value label: cytoskeletal protein binding
  P681:
    value: Q40260
    source count: 1
    confidence: 0.2
    value label: nucleus
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q154626
    source count: 2
    confidence: 0.4
    value label: cytoskeleton

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14599698
source count: 2
confidence: 0.4
value label: negative regulation of cell growth

value: Q14633911
source count: 1
confidence: 0.2
value label: regulation of apoptotic process

value: Q14818129
source count: 1
confidence: 0.2
value label: regulation of cell cycle

value: Q24405829
source count: 1
confidence: 0.2
value label: Nf2

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000010690
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells
stated in qid: Q28583992
retrieved: 2019-02-14

source: Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells
stated in qid: Q28580870
retrieved: 2019-02-14

source: A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
stated in qid: Q24299493
retrieved: 2019-02-14

source: The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
stated in qid: Q28363493
retrieved: 2019-02-14

source: Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells
stated in qid: Q28583781
retrieved: 2019-02-14

source: Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system
stated in qid: Q28575792
retrieved: 2019-02-14

source: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development
stated in qid: Q28575612
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28561856
domain: protein
level: standard
html url: https://4ort.xyz/entity/nf2-moesin-ezrin-radixin-like-merlin-tumor-suppressor
markdown url: https://4ort.xyz/entity/nf2-moesin-ezrin-radixin-like-merlin-tumor-suppressor.md
facts url summary: https://4ort.xyz/entity/nf2-moesin-ezrin-radixin-like-merlin-tumor-suppressor/facts.json
facts url standard: https://4ort.xyz/entity/nf2-moesin-ezrin-radixin-like-merlin-tumor-suppressor/facts.json
facts url full: https://4ort.xyz/entity/nf2-moesin-ezrin-radixin-like-merlin-tumor-suppressor/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T08:33:31.207385Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:13:20.947238+00:00Z