# neutrophil elastase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3721138](https://www.wikidata.org/wiki/Q3721138)  
**Source**: https://4ort.xyz/entity/neutrophil-elastase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3617964)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08246)
5. Q20641742
6. Freebase Data Dumps. 2013
7. [Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
8. [Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
9. [Killing activity of neutrophils is mediated through activation of proteases by K+ flux](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
10. [Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
11. [Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
13. [Proteolysis of human thrombin generates novel host defense peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
14. [Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
15. [Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
16. [Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
17. [Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
18. [Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
20. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
21. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
22. [Proteolysis of human thrombin generates novel host defense peptides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
23. [Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
24. [Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
25. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
26. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
27. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
28. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
29. [Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
30. [Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
32. [Killing activity of neutrophils is mediated through activation of proteases by K+ flux](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08246&geneProductId=UniProtKB:P08246)
33. [The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
34. [UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
35. [Human neutrophil-derived elastase induces airway smooth muscle cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08246)
36. Ensembl Release 99
37. UMLS 2023