Neurotrophic receptor tyrosine kinase 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: entrectinib
additional property: PropertyValue
  property ID: P129
  value: altiratinib
additional property: PropertyValue
  property ID: P129
  value: milciclib
additional property: PropertyValue
  property ID: P352
  value: P04629
additional property: PropertyValue
  property ID: P361
  value: tyrosine-protein kinase, neurotrophic receptor, type 1
additional property: PropertyValue
  property ID: P361
  value: Leucine-rich repeat domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P527
  value: tyrosine-protein kinase, active site
additional property: PropertyValue
  property ID: P527
  value: cysteine-rich flanking region, C-terminal
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P637
  value: NP_001007793
additional property: PropertyValue
  property ID: P637
  value: NP_001012331
additional property: PropertyValue
  property ID: P637
  value: NP_002520
additional property: PropertyValue
  property ID: P638
  value: 1HE7
additional property: PropertyValue
  property ID: P638
  value: 1SHC
additional property: PropertyValue
  property ID: P638
  value: 1WWA
additional property: PropertyValue
  property ID: P680
  value: neurotrophin binding
additional property: PropertyValue
  property ID: P680
  value: GPI-linked ephrin receptor activity
additional property: PropertyValue
  property ID: P680
  value: neurotrophin receptor activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: negative regulation of neuron apoptotic process
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of Ras protein signal transduction
additional property: PropertyValue
  property ID: P692
  value: PBB GE NTRK1 208605 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: NTRK1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000376120
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 34
      unique citations norm: 0.013
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 34
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q25323953
    source count: 1
    confidence: 0.2
    value label: entrectinib
  P129:
    value: Q27074416
    source count: 1
    confidence: 0.2
    value label: altiratinib
  P129:
    value: Q27086363
    source count: 1
    confidence: 0.2
    value label: milciclib
  P352:
    value: P04629
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726467
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, neurotrophic receptor, type 1
  P361:
    value: Q24781235
    source count: 1
    confidence: 0.2
    value label: Leucine-rich repeat domain superfamily
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q41797304
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like domain superfamily
  P527:
    value: Q24738472
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, active site
  P527:
    value: Q24782645
    source count: 1
    confidence: 0.2
    value label: cysteine-rich flanking region, C-terminal
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24768234
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    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24783253
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    confidence: 0.2
    value label: immunoglobulin-like domain
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    confidence: 0.2
  P637:
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  P637:
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  P638:
    value: 1HE7
    source count: 1
    confidence: 0.2
  P638:
    value: 1SHC
    source count: 1
    confidence: 0.2

value: 1WWA
source count: 1
confidence: 0.2

value: 1WWW
source count: 1
confidence: 0.2

value: 2IFG
source count: 1
confidence: 0.2

value: Q14897680
source count: 1
confidence: 0.2
value label: neurotrophin binding

value: Q21101172
source count: 1
confidence: 0.2
value label: GPI-linked ephrin receptor activity

value: Q14897873
source count: 1
confidence: 0.2
value label: neurotrophin receptor activity

value: Q14863082
source count: 1
confidence: 0.2
value label: kinase activity

value: Q14817981
source count: 2
confidence: 0.4
value label: ATP binding

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q824237
source count: 2
confidence: 0.4
value label: endosome

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q14904869
source count: 1
confidence: 0.2
value label: late endosome membrane

value: Q189094
source count: 1
confidence: 0.2
value label: cell surface

value: Q14820618
source count: 2
confidence: 0.4
value label: negative regulation of neuron apoptotic process

value: Q14819846
source count: 2
confidence: 0.4
value label: positive regulation of protein phosphorylation

value: Q14852019
source count: 1
confidence: 0.2
value label: positive regulation of Ras protein signal transduction

value: Q14897687
source count: 2
confidence: 0.4
value label: positive regulation of programmed cell death

value: Q21115599
source count: 1
confidence: 0.2
value label: behavioral response to formalin induced pain

value: PBB GE NTRK1 208605 s at fs.png
source count: 0
confidence: 0.0

value: Q14897694
source count: 1
confidence: 0.2
value label: NTRK1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000376120
source count: 1
confidence: 0.2

value: ENSP00000431418
source count: 1
confidence: 0.2

value: ENSP00000357179
source count: 1
confidence: 0.2

value: ENSP00000351486
source count: 1
confidence: 0.2

value: ENSP00000436804
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/P04629
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Structure and organization of the humanTRKA gene encoding a high affinity receptor for nerve growth factor
stated in qid: Q24310833
retrieved: 2017-09-26

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-26

source: Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors
stated in qid: Q24338527
retrieved: 2019-04-08

source: Nerve growth factor mediates signal transduction through trk homodimer receptors
stated in qid: Q28854581
retrieved: 2019-04-08

source: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma
stated in qid: Q24307374
retrieved: 2019-04-08

source: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
stated in qid: Q41002813
retrieved: 2019-04-08

source: GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival
stated in qid: Q36337031
retrieved: 2019-04-08

source: Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity
stated in qid: Q24294527
retrieved: 2019-04-08

source: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
stated in qid: Q24307989
retrieved: 2019-04-08

source: Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
stated in qid: Q28593429
retrieved: 2019-04-08

source: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
stated in qid: Q22010543
retrieved: 2019-04-08

source: Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl
stated in qid: Q24302303
retrieved: 2019-04-08

source: Sortilin is essential for proNGF-induced neuronal cell death
stated in qid: Q24312692
retrieved: 2019-04-08

source: The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities
stated in qid: Q24306901
retrieved: 2019-04-08

source: Molecular and biochemical characterization of the human trk proto-oncogene
stated in qid: Q28854584
retrieved: 2017-09-26

source: Nerve growth factor mediates signal transduction through trk homodimer receptors
stated in qid: Q28854581
retrieved: 2017-09-26

source: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma
stated in qid: Q24307374
retrieved: 2017-09-26

source: Molecular and biochemical characterization of the human trk proto-oncogene
stated in qid: Q28854584
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Structure and organization of the humanTRKA gene encoding a high affinity receptor for nerve growth factor
stated in qid: Q24310833
retrieved: 2019-04-08

source: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins
stated in qid: Q24314344
retrieved: 2017-09-26

source: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins
stated in qid: Q24314344
retrieved: 2019-04-08

source: A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis
stated in qid: Q24318622
retrieved: 2019-04-08

source: Involvement of Insulin-Like Growth Factor 1 Receptor Signaling in the Amyloid-β Peptide Oligomers-Induced p75 Neurotrophin Receptor Protein Expression in Mouse Hippocampus
stated in qid: Q39341361
retrieved: 2019-04-08

source: Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines
stated in qid: Q41792400
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

wikidata id: Q4051790
domain: protein
level: standard
html url: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790
markdown url: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790.md
facts url summary: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790/facts.json
facts url standard: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790/facts.json
facts url full: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T20:00:24.914062Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:21:49.149778+00:00Z