# Neurotrophic receptor tyrosine kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4051790](https://www.wikidata.org/wiki/Q4051790)  
**Source**: https://4ort.xyz/entity/neurotrophic-receptor-tyrosine-kinase-1-q4051790


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1983268)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545365)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL564829)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04629)
6. Q20641742
7. [Structure and organization of the humanTRKA gene encoding a high affinity receptor for nerve growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
10. [Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
11. [Nerve growth factor mediates signal transduction through trk homodimer receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
12. [TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
13. [Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
14. [GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
15. [Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
16. [Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
17. [Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
18. [Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
19. [Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
20. [Sortilin is essential for proNGF-induced neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
21. [The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
22. [Molecular and biochemical characterization of the human trk proto-oncogene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
23. [Nerve growth factor mediates signal transduction through trk homodimer receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
24. [TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
25. [Molecular and biochemical characterization of the human trk proto-oncogene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
27. [Structure and organization of the humanTRKA gene encoding a high affinity receptor for nerve growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
28. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04629&geneProductId=UniProtKB:P04629)
29. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
30. [A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
31. [Involvement of Insulin-Like Growth Factor 1 Receptor Signaling in the Amyloid-β Peptide Oligomers-Induced p75 Neurotrophin Receptor Protein Expression in Mouse Hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
32. [Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04629)
33. Ensembl Release 99
34. Identifiers.org