Neuropilin 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O14786
additional property: PropertyValue
  property ID: P361
  value: Spermadhesin, CUB domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Concanavalin A-like lectin/glucanase domain superfamily
additional property: PropertyValue
  property ID: P361
  value: neuropilin-1
additional property: PropertyValue
  property ID: P527
  value: Neuropilin, C-terminal
additional property: PropertyValue
  property ID: P527
  value: MAM domain
additional property: PropertyValue
  property ID: P527
  value: CUB domain
additional property: PropertyValue
  property ID: P637
  value: NP_001019799
additional property: PropertyValue
  property ID: P637
  value: NP_001019800
additional property: PropertyValue
  property ID: P637
  value: NP_001231901
additional property: PropertyValue
  property ID: P638
  value: 1KEX
additional property: PropertyValue
  property ID: P638
  value: 2QQI
additional property: PropertyValue
  property ID: P638
  value: 2QQM
additional property: PropertyValue
  property ID: P680
  value: heparin binding
additional property: PropertyValue
  property ID: P680
  value: vascular endothelial growth factor binding
additional property: PropertyValue
  property ID: P680
  value: cytokine binding
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P682
  value: negative regulation of neuron apoptotic process
additional property: PropertyValue
  property ID: P682
  value: facioacoustic ganglion development
additional property: PropertyValue
  property ID: P682
  value: vascular endothelial growth factor signaling pathway
additional property: PropertyValue
  property ID: P702
  value: NRP1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000265371
additional property: PropertyValue
  property ID: P705
  value: ENSP00000363954
additional property: PropertyValue
  property ID: P705
  value: ENSP00000363955
additional property: PropertyValue
  property ID: P7260
  value: 8.A.47.1.5
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 25
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 25
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O14786
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797064
    source count: 1
    confidence: 0.2
    value label: Spermadhesin, CUB domain superfamily
  P361:
    value: Q24722342
    source count: 1
    confidence: 0.2
    value label: Concanavalin A-like lectin/glucanase domain superfamily
  P361:
    value: Q24723019
    source count: 1
    confidence: 0.2
    value label: neuropilin-1
  P361:
    value: Q24780736
    source count: 1
    confidence: 0.2
    value label: Galactose-binding-like domain superfamily
  P361:
    value: Q67141865
    source count: 1
    confidence: 0.2
    value label: auxiliary protein involved in transmembrane transport
  P527:
    value: Q24779388
    source count: 1
    confidence: 0.2
    value label: Neuropilin, C-terminal
  P527:
    value: Q24721462
    source count: 1
    confidence: 0.2
    value label: MAM domain
  P527:
    value: Q24774207
    source count: 1
    confidence: 0.2
    value label: CUB domain
  P527:
    value: Q24727589
    source count: 1
    confidence: 0.2
    value label: coagulation factor 5/8 C-terminal domain
  P637:
    value: NP_001019799
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001019800
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001231901
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001231902
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001316997
    source count: 1
    confidence: 0.2
  P638:
    value: 1KEX
    source count: 1
    confidence: 0.2
  P638:
    value: 2QQI
    source count: 1
    confidence: 0.2
  P638:
    value: 2QQM
    source count: 1
    confidence: 0.2
  P638:
    value: 2QQN
    source count: 1
    confidence: 0.2
  P638:
    value: 3I97
    source count: 1
    confidence: 0.2

value: Q14819453
source count: 1
confidence: 0.2
value label: heparin binding

value: Q21102505
source count: 2
confidence: 0.4
value label: vascular endothelial growth factor binding

value: Q14874270
source count: 1
confidence: 0.2
value label: cytokine binding

value: Q21107506
source count: 3
confidence: 0.6
value label: semaphorin receptor activity

value: Q14865163
source count: 1
confidence: 0.2
value label: coreceptor activity

value: Q220599
source count: 1
confidence: 0.2
value label: cytosol

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q14645596
source count: 1
confidence: 0.2
value label: extracellular region

value: Q21108960
source count: 1
confidence: 0.2
value label: semaphorin receptor complex

value: Q189094
source count: 1
confidence: 0.2
value label: cell surface

value: Q14820618
source count: 1
confidence: 0.2
value label: negative regulation of neuron apoptotic process

value: Q21114529
source count: 1
confidence: 0.2
value label: facioacoustic ganglion development

value: Q14912397
source count: 1
confidence: 0.2
value label: vascular endothelial growth factor signaling pathway

value: Q21114528
source count: 1
confidence: 0.2
value label: VEGF-activated neuropilin signaling pathway involved in axon guidance

value: Q21100636
source count: 1
confidence: 0.2
value label: toxin transport

value: Q18033463
source count: 1
confidence: 0.2
value label: NRP1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000265371
source count: 1
confidence: 0.2

value: ENSP00000363954
source count: 1
confidence: 0.2

value: ENSP00000363955
source count: 1
confidence: 0.2

value: ENSP00000364001
source count: 1
confidence: 0.2

value: ENSP00000363949
source count: 1
confidence: 0.2

value: 8.A.47.1.5
source count: 2
confidence: 0.4

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
stated in qid: Q24318367
retrieved: 2019-04-08

source: The role of neuropilins in cell signalling
stated in qid: Q24316500
retrieved: 2019-04-08

source: Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
stated in qid: Q24337623
retrieved: 2019-04-08

source: Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
stated in qid: Q24310596
retrieved: 2019-04-08

source: Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
stated in qid: Q24321564
retrieved: 2019-04-08

source: Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
stated in qid: Q27331901
retrieved: 2019-04-08

source: Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
stated in qid: Q24293042
retrieved: 2019-04-08

source: Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
stated in qid: Q24292998
retrieved: 2019-04-08

source: The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover
stated in qid: Q24324024
retrieved: 2019-04-08

source: Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells
stated in qid: Q30579734
retrieved: 2019-04-08

source: NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
stated in qid: Q40036220
retrieved: 2019-04-08

source: The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis
stated in qid: Q24339531
retrieved: 2019-04-08

source: Human colostrum: identification of minor proteins in the aqueous phase by proteomics
stated in qid: Q24305934
retrieved: 2017-10-17

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-17

source: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
stated in qid: Q24297812
retrieved: 2017-10-17

source: Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells
stated in qid: Q30579734
retrieved: 2017-10-17

source: Human colostrum: identification of minor proteins in the aqueous phase by proteomics
stated in qid: Q24305934
retrieved: 2019-04-08

source: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
stated in qid: Q24297812
retrieved: 2019-04-08

source: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex
stated in qid: Q33594808
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21114530
domain: protein
level: standard
html url: https://4ort.xyz/entity/neuropilin-1
markdown url: https://4ort.xyz/entity/neuropilin-1.md
facts url summary: https://4ort.xyz/entity/neuropilin-1/facts.json
facts url standard: https://4ort.xyz/entity/neuropilin-1/facts.json
facts url full: https://4ort.xyz/entity/neuropilin-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T08:41:29.222400Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:18.107337+00:00Z