# Neurofilament, light polypeptide

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987272](https://www.wikidata.org/wiki/Q21987272)  
**Source**: https://4ort.xyz/entity/neurofilament-light-polypeptide


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08551)
3. Q20641742
4. [The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
6. [Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
7. [RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
8. [Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
9. [A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
10. [Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
11. [The cytoskeleton of the myenteric neurons during murine embryonic life](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
12. [In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
13. [Expression of catenins during mouse embryonic development and in adult tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
14. [Proteolipid protein is required for transport of sirtuin 2 into CNS myelin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08551&geneProductId=UniProtKB:P08551)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08551&geneProductId=UniProtKB:P08551)
16. [Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
17. [Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
18. [Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
19. [Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
20. [Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
21. [Proteolipid protein is required for transport of sirtuin 2 into CNS myelin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
22. [Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
23. [A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
24. [Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
25. [Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
26. [Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
27. [Delayed Maturation of Regenerating Myelinated Axons in Mice Lacking Neurofilaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
28. [Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
29. [Late onset of motor neurons in mice overexpressing wild-type peripherin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
30. [Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
31. [Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
32. [Neurofilament transport in vivo minimally requires hetero-oligomer formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
33. [No requirement of alpha-internexin for nervous system development and for radial growth of axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551)
34. ensembl Release 106