# Neurofibromin 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987763](https://www.wikidata.org/wiki/Q21987763)  
**Source**: https://4ort.xyz/entity/neurofibromin-1-q21987763


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
4. [Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
5. [Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
6. [Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
7. [Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
8. [Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04690&geneProductId=UniProtKB:Q04690)
10. [JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
11. [Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
12. [Nf1 haploinsufficiency augments angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
13. [Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
14. [Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
15. [Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
16. [Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
17. [Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
18. [Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
19. [Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
20. [Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
21. [Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
22. [Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
23. [Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
24. [Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
25. [The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
26. [In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
27. [Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
28. [Nf1 has an essential role in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
29. [Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
30. [The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
31. [Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
32. [Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
33. [Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
34. [Mouse models of tumor development in neurofibromatosis type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
35. [Mouse tumor model for neurofibromatosis type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
36. [Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
37. [Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
38. [Neurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
39. [Tumour predisposition in mice heterozygous for a targeted mutation in Nf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
40. [Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
41. [Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
42. [An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
43. [Neurofibromin regulates G protein-stimulated adenylyl cyclase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
44. [Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
45. [Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
46. [Induction of melanogenic abnormalities in NF1+/- mutant mice by DMBA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
47. [The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
48. [Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
49. [A mouse model for the learning and memory deficits associated with neurofibromatosis type I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)
50. [The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690)